Endocrine Abstracts

Arginine vasopressin (AVP) is secreted via exocytosis; however, the precise molecular mechanism underlying the exocytosis of AVP is unknown. To better understand the mechanisms of AVP secretion, here we study to identify proteins that bind with a 25 kDa synaptosomal-associated protein (SNAP25), a protein that plays a crucial role in exocytosis, in the posterior pituitary. Embryonic stem (ES) cell-derived AVP neurons were established to investigate the functions of the identifi...

Rapid correction of chronic hyponatremia can cause osmotic demyelination syndrome(ODS). Recent days, vasopressin receptor antagonists(VAs) are clinically used for the treatment of congestive heart failure or hyponatremia including SIADH. To date, few cases of ODS caused by VAs have reported; however, it is presumed that the treatment with VAs for severe hyponatremia may be associated with an increased risk of ODS. Therefore, in this study, we investigated whether rapid correct...

Rab proteins (Rab GTPase) have been implicated in the trafficking and exocytosis of secretary vesicle and play a central role in the secretion of hormones or neurotransmitters. However, the involvement of Rabs and Rab effectors in the regulation of AVP secretion is still unknown. Embryonic stem (ES) cells are pluripotent cells that differentiate into all cell types. Recently, it has been reported that when dissociated ES cells are quickly reaggregeted in low cell-adhesion cult...